Deletion of the thymidine kinase gene attenuates Caprine alphaherpesvirus 1 in goats

Jéssica Caroline Gomes Noll, **Lok RajJoshi**, Gabriela Mansanodo Nascimento, Maureen Hoch Vieira Fernandes, Bishwas Sharma, Eduardo Furtado Flores, Diego Gustavo Diel

October 2019

Source Document

Type

Journal article

Publication

Veterinary Microbiology

Highlights

•Deletion of the tk gene from the CpHV-1 genome attenuates the virus in goats.

•Traditional infection/transfection resulted in efficient CpHV-1 recombination.

•Both parental and tk-deleted viruses established latency in neurons of the trigeminal ganglia.