Pathogenesis of Picornavirus
Senecavirus A is a re-emergiging disease of swine. It causes vesicular disease in swine. Despite detection of Senecavirus A nucleic acid in pigs with vesicular disease, attemps to establish causal relationship had failed. We were able to reproduce the disease in swine and we have published a detail pathogenesis of Senecavirus A in this paper. We have also showed that the virus establishes persistent infection in infected animal.
Lok Raj Joshi
Postdoctoral Research Fellow
My research interests include AAV gene therapy, vectored vaccine development, viral pathogenesis, diagnostic assay development,reverse genetics, viral bioinformatics.
Publications
Persistent Infection and Transmission of Senecavirus A from Carrier Sows to Contact Piglets
Abstract Senecavirus A (SVA) is a picornavirus that causes acute vesicular disease (VD), that is clinically indistinguishable from foot-and-mouth disease (FMD), in pigs. Notably, SVA RNA has been detected in lymphoid tissues of infected animals several weeks following resolution of the clinical disease, suggesting that the virus may persist in select host tissues.
Adaptive immune responses following Senecavirus A infection in pigs
Abstract
Senecavirus A (SVA), an emerging picornavirus of swine, causes vesicular disease (VD) that is clinically indistinguishable from foot-and-mouth disease (FMD) in pigs. Many aspects of SVA interactions with the host and the host immune responses to infection, however, remain unknown.
